https://doi.org/10.4081/hmr.v2i7.420
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Progress in the treatment of diffuse large B-cell lymphomas: a German perspective

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M Pfreundschuh
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Young good-prognosis patients comprise the low and low-intermediate risk group (risk factor 0 and 1 according to the age-adjusted IPI) while poor-prognosis patients comprise the high-intermediate and high risk group (≥2 risk factors). Optimum treatment responses in young good-prognosis patients have so far been achieved with 6 cycles of a CHOP-like chemotherapy in combination with the anti-CD20 antibody rituximab. Using this therapeutic approach, 3-year event-free survival rates of >90% and overall survival of >97% can be achieved in a very favorable subgroup (patients without IPI risk factor and no bulky disease), while further improvement is warranted for the less favorable subgroup (IPI=I and/or bulky disease; 3-year event-free survival: 77%).

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Pfreundschuh, M. (2009). Progress in the treatment of diffuse large B-cell lymphomas: a German perspective. Hematology Meeting Reports (formerly Haematologica Reports), 2(7). https://doi.org/10.4081/hmr.v2i7.420
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