https://doi.org/10.4081/hmr.v2i7.398

Novel pathogenetic mechanisms and therapeutic targets in B cell lymphomas

Vol. 2 No. 7: New Insights in Hematology, Venice (Italy), May 14-17, 2006
Published: June 8, 2009
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R Dalla-Favera
support@pagepress.org
B cell derived Non-Hodgkin Lymphoma (B-NHL), including Burkitt lymphoma (BL and diffuse large B cell lymphoma (DLBCL) developing in children, represent a heterogeneous group of malignancies that arise by malignant transformation of B cells within the germinal center (GC). Within GC, antigen-stimulated B cells undergo rapid proliferation and specific genome remodeling processes such as Immunoglobulin (Ig) somatic hypermutation (SHM), and class switch recombination (CSR).

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Dalla-Favera, R. (2009). Novel pathogenetic mechanisms and therapeutic targets in B cell lymphomas. Hematology Meeting Reports (formerly Haematologica Reports), 2(7). https://doi.org/10.4081/hmr.v2i7.398
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