https://doi.org/10.4081/hmr.v2i5.382

Bortezomib in newly diagnosed multiple myeloma patients

Vol. 2 No. 5: Bortezomib (Velcade®) in multiple myeloma: an update
Published: June 8, 2009
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Authors

Silvia Mangiacavalli
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High-dose therapy represents today the standard of care for younger multiple myeloma (MM) patients candidates to transplant. The induction phase is performed usually with VAD or VAD-like schemes which, however, produce a complete remission rate (CR) in less than 10%. Bortezomib (Velcade®) has demonstrated to be very effective in relapsed/refractory myeloma patients giving as single agent a CR rate of 16%, and several evidences indicate that bortezomib shows a synergistic activity with dexamethasone or other cytotoxic agents. Thus, taking into account that the achievement of a CR is the main objective in the treatment of MM, it is reasonable to introduce Bortezomib (Velcade®) as part of front-line high-dose programs. The application of bortezomib to novel front-line therapies depends in part on its effects on subsequent stem cell mobilization and engraftment.

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Mangiacavalli, S. (2009). Bortezomib in newly diagnosed multiple myeloma patients. Hematology Meeting Reports (formerly Haematologica Reports), 2(5). https://doi.org/10.4081/hmr.v2i5.382
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