Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours

Published: June 8, 2009
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Zoledronic acid (Zometa) is increasingly used to treat tumour-induced bone disease, and is also reported to have anti-angiogenic properties in vivo.1,2 In this study we have investigated the correlations between changes in the pro-angiogenic cytokine VEGF and markers of bone resorption in a cohort of patients with metastatic bone disease, following a single infusion of zoledronic acid.

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Vincenzi, B., Santini, D., Holen, I., & Tonini, G. (2009). Changes in bone resorption and vascular endothelial growth factor after a single zoledronic acid infusion in cancer patients with bone metastases from solid tumours. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.375