https://doi.org/10.4081/hmr.v2i3.374

The effects of combined treatment using paclitaxel and zoledronic acid on tumour cells and endothelial cells in vitro

Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
Abstract Views: 217
PDF: 430
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Authors

M Michailidou
support@pagepress.org
HL Neville-Webbe
JK Woodward
DV Lefley
There is increasing use of combined therapies in oncology, but the optimal drug combinations and sequences have in many cases not been determined. The use of bisphosphonates (BPs) together with cytotoxic drugs may be a favourable combination, as BPs like Zometa are usually well tolerated causing few side effects in the patients.1 In this study we have investigating the effects of zoledronic acid (Zometa) in combination with the commonly used cytotoxic drug paclitaxel, in order to determine whether this combination does induce increased levels of apoptotic cell death in breast cancer cells in vitro.2

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Michailidou, M., Neville-Webbe, H., Woodward, J., & Lefley, D. (2009). The effects of combined treatment using paclitaxel and zoledronic acid on tumour cells and endothelial cells in vitro. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.374
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