https://doi.org/10.4081/hmr.v2i3.369

Single cell monitoring of trogocytosis and killing in lytic synapses between anaplastic large cell lymphoma and activated human γδ T lymphocytes

Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
Abstract Views: 185
PDF: 196
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Authors

JJ Fournié
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J Gertner
M Poupot
A Wiedemann
Circulating human γδ T lymphocytes comprise a unique lymphoid cell subset exerting strong cytolytic activity against cancer cells.1 In healthy adults, around 1% of peripheral blood mononuclear cells are gd T lymphocytes, most of which harbour a CD3+ CD4– CD8– NKG2D+ phenotype and express the same TCR Vγ9/dδ2 gene-encoded receptor for antigens. These lymphocytes often referred to as Vγ9/V2δ+ T cells do respond to both human cancer cells and tuberculosis infection, by the selective recognition of HLA-unrestricted antigens with non-peptide phosphoesters structures, the phosphoantigens.2

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Fournié, J., Gertner, J., Poupot, M., & Wiedemann, A. (2009). Single cell monitoring of trogocytosis and killing in lytic synapses between anaplastic large cell lymphoma and activated human γδ T lymphocytes. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.369
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