https://doi.org/10.4081/hmr.v2i3.368

Distribution of γδ T cells in patients with hematological malignancies

Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
Abstract Views: 164
PDF: 129
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

S Mariani
support@pagepress.org
F Pantaleoni
S Peola
Tumor progression in multiple myeloma (MM) is due to intrinsic features of myeloma cells and to interactions of myeloma cells with the bone marrow microenvironment. Beside promoting myeloma cell survival and proliferation, these interactions are responsible for: 1) the activation and differentiation of osteoclast precursors into mature osteoclasts, yielding to bone resorption and lytic lesions, 2) the angiogenic switch sustained by endothelial cells and other stromal cells, via paracrine and autocrine loops, involving multiple VEGF/VEGF-R and other pathways; 3) a progressive immune failure that is responsible for the enhanced susceptibility to infections of MM patients and the escape of myeloma cells to host immune surveillance.

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Supporting Agencies

How to Cite

Mariani, S., Pantaleoni, F., & Peola, S. (2009). Distribution of γδ T cells in patients with hematological malignancies. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.368
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).