Towards therapeutic stimulations of gd T cells

Published: June 8, 2009
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Most vaccine strategies are designed to elicit adaptive immune responses to a variety of microbial or tumor-associated antigens. These immune responses are predominantly mediated by αβ T cells, B cells and antibodies. Nevertheless, approximately 1-5% of human peripheral blood lymphocytes possess the surface gd T-cell receptor, predominantly expressing the Vγ9Vδ2 variable segments.

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Malkovsky, M., Wallace, M., McNeel, D., Liu, G., Mejia, G., Kaikobad, M., Waterman, P., Samaniego, E., Bonneville, M., Fournie, J., Sicard, H., & Poccia, F. (2009). Towards therapeutic stimulations of gd T cells. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.367