The farnesyl-transferase r115777 and the aminobisphosphonate zoledronic acid synergize on the apoptosis and on the growth inhibition of human cancer cells

Published: June 8, 2009
Abstract Views: 170
Untitled (): 0
PDF: 144
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Pamidronate (PAM) and Zoledronic Acid (ZOL) are aminobisphosphonate (BPs) able to affect the isoprenylation of intracellular small G-proteins. We have investigated the antitumor activity of BPs and R115777 farnesyltransferase inhibitor (FTI) against epidermoid cancer cells. In human epidermoid head and neck KB and lung H1355 cancer cells 48 h exposure to PAM and ZOL induced growth inhibition (IC50 25 µM and 10 µM, respectively) and apoptosis and abolished the proliferative and anti-apoptotic stimuli induced by epidermal growth factor (EGF).

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Supporting Agencies

How to Cite

Caraglia, M., Marra, M., Leonetti, C., Meo, G., Addeo, S. R., Bruzzese, F., Tagliaferri, P., Zupi, G., Abbruzzese, A., & Budillon, A. (2009). The farnesyl-transferase r115777 and the aminobisphosphonate zoledronic acid synergize on the apoptosis and on the growth inhibition of human cancer cells. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.366