The farnesyl-transferase r115777 and the aminobisphosphonate zoledronic acid synergize on the apoptosis and on the growth inhibition of human cancer cells

Published: June 8, 2009
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Pamidronate (PAM) and Zoledronic Acid (ZOL) are aminobisphosphonate (BPs) able to affect the isoprenylation of intracellular small G-proteins. We have investigated the antitumor activity of BPs and R115777 farnesyltransferase inhibitor (FTI) against epidermoid cancer cells. In human epidermoid head and neck KB and lung H1355 cancer cells 48 h exposure to PAM and ZOL induced growth inhibition (IC50 25 µM and 10 µM, respectively) and apoptosis and abolished the proliferative and anti-apoptotic stimuli induced by epidermal growth factor (EGF).

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Caraglia, M., Marra, M., Leonetti, C., Meo, G., Addeo, S. R., Bruzzese, F., Tagliaferri, P., Zupi, G., Abbruzzese, A., & Budillon, A. (2009). The farnesyl-transferase r115777 and the aminobisphosphonate zoledronic acid synergize on the apoptosis and on the growth inhibition of human cancer cells. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.366