New insights into the molecular actions of nitrogen-containing bisphosphonates

Published: June 8, 2009
Abstract Views: 141
Untitled (): 0
PDF: 561
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

About 10 years ago it was found that mammalian cells could convert some bisphosphonates (BPs) intracellularly into methylene-containing (AppCp-type) analogues of ATP, that accumulate in the cytosol,1,2 reviewed recently.3 Only simple BPs (ie those that most closely resemble PPi, such as clodronate and etidronate, but not alendronate, pamidronate or other N-BPs) appear to be metabolised.2

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Supporting Agencies

How to Cite

Rogers, M. (2009). New insights into the molecular actions of nitrogen-containing bisphosphonates. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.364