https://doi.org/10.4081/hmr.v2i3.364

New insights into the molecular actions of nitrogen-containing bisphosphonates

Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
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MJ Rogers
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About 10 years ago it was found that mammalian cells could convert some bisphosphonates (BPs) intracellularly into methylene-containing (AppCp-type) analogues of ATP, that accumulate in the cytosol,1,2 reviewed recently.3 Only simple BPs (ie those that most closely resemble PPi, such as clodronate and etidronate, but not alendronate, pamidronate or other N-BPs) appear to be metabolised.2

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Rogers, M. (2009). New insights into the molecular actions of nitrogen-containing bisphosphonates. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.364
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