https://doi.org/10.4081/hmr.v2i3.359

A subset of Vγ9Vδ2 T cells help B cells for antibody production

Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
Abstract Views: 229
PDF: 354
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Authors

N Caccamo
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S Meraviglia
C La Mendola
S Buccheri
M D’Asaro
F Dieli
A Salerno
Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in antibody-mediated immune responses. Here we report on the identification of a unique subset of Vγ9Vδ2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4 and IL-10 and help B cells for antibody production. These properties portray CXCR5+ Vγ9Vδ2 T cells as a distinct memory T cell subset with B cell helper function.

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Caccamo, N., Meraviglia, S., La Mendola, C., Buccheri, S., D’Asaro, M., Dieli, F., & Salerno, A. (2009). A subset of Vγ9Vδ2 T cells help B cells for antibody production. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.359
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