A subset of Vγ9Vδ2 T cells help B cells for antibody production

Published: June 8, 2009
Abstract Views: 240
PDF: 364
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Vγ9Vδ2 T lymphocytes recognize nonpeptidic antigens and mount effector functions in cellular immune responses against microorganisms and tumors, but little is known about their role in antibody-mediated immune responses. Here we report on the identification of a unique subset of Vγ9Vδ2 T cells which express the costimulatory molecules ICOS and CD40L, secrete IL-2, IL-4 and IL-10 and help B cells for antibody production. These properties portray CXCR5+ Vγ9Vδ2 T cells as a distinct memory T cell subset with B cell helper function.

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Supporting Agencies

How to Cite

Caccamo, N., Meraviglia, S., La Mendola, C., Buccheri, S., D’Asaro, M., Dieli, F., & Salerno, A. (2009). A subset of Vγ9Vδ2 T cells help B cells for antibody production. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.359