https://doi.org/10.4081/hmr.v2i3.358

Human memory Vγ9Vδ2 T cells require homeostatic cytokines for proliferation and differentiation

Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
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PDF: 264
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Authors

N Caccamo
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S Meraviglia
V Ferlazzo
F Dieli
G Guggino
C La Mendola
A Salerno
We have analysed four subsets of human γg9Vδ2 T cells for their capacity to proliferate and differentiate in response to antigen or homeostatic cytokines. Antigen-stimulated cells acquired a central memory (TCM) or effector memory (TEM) phenotype, while IL-15-stimulated cells maintained their phenotype, with the exception of TCM cells, which expressed CD27 and CD45RA in various combinations. These results show that huma nVγ9Vδ2 memory T cells have different proliferation and differentiation potentials and that terminally differentiated (TEMRA) cells result from the TCM subset upon homeostatic proliferation in the absence of antigen.

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Caccamo, N., Meraviglia, S., Ferlazzo, V., Dieli, F., Guggino, G., La Mendola, C., & Salerno, A. (2009). Human memory Vγ9Vδ2 T cells require homeostatic cytokines for proliferation and differentiation. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.358
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