https://doi.org/10.4081/hmr.v2i3.357

TLR3 ligand induces a direct costimulatory effect on phoshoantigen stimulated human γδ T cells, but not on aminobisphosphonate-stimulated human γδ T cells

Vol. 2 No. 3: Cervo Preclinical Working Conference, Cervo Ligure, October 6-8, 2005
Published: June 8, 2009
Abstract Views: 119
PDF: 218
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Authors

D Wesch
support@pagepress.org
S Beetz
D Kabelitz
γδT cells expressing Vγ9 paired withVδ2 account for up to 95% of γδ T cells in the peripheral blood.1 These cells recognize phosphorylated, nonproteinaceous intermediates of the non-mevalonate pathway of the bacterial isoprenoid biosynthesis pathway (phosphoantigens).2 Additionally, the same subset of VγδVd2 T cells has been shown to be activated by therapeutically used aminobisphosphonate.3 Moreover, VγδVd2 T cells express MHC class I- or MICA/B (MHC class I related molecules)-specific natural killer-inhibitory receptors such as NKG2A and natural killer-activating receptors such as NKG2D, which can modulate reactivity towards e.g. phosphoantigens.4,5

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Wesch, D., Beetz, S., & Kabelitz, D. (2009). TLR3 ligand induces a direct costimulatory effect on phoshoantigen stimulated human γδ T cells, but not on aminobisphosphonate-stimulated human γδ T cells. Hematology Meeting Reports (formerly Haematologica Reports), 2(3). https://doi.org/10.4081/hmr.v2i3.357
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