Nodal aggressive non-Hodgkin’s lymphoma in the adult: a review article

Background. The term aggressive lymphoma is a clinical definition encompassing different lymphoid tumurs which are potentially curable, but run a rapidly fatal course if not properly treated. Under this definition, no longer quoted in the REAL/WHO Classification, several histotypes are included that differ remarkably in cell size and morphology, phenotypic and molecular characteristics, kinetics and clinical presentation. Tailored approaches have been designed aiming to adapt therapy to each specific histotype. Aim and design. Since aggressive lymphomas account for the majority of lymphoid neoplasms, and because some variation exists as to their categorization and treatment, the authors will discuss the more recent and consolidated findings in the etiology, pathogenesis, histopathology, diagnostics and therapy of such tumours based on both the evidence in the literature and their own expertise. In particular, each tumour type is individually discussed, as are the most critical areas in patient management. Conclusions. An updated review of more recent biological and therapeutic aspects is intended to assist the hematologist, pathologist and practitioner in the optimal management of patients with aggressive lymphoma. Key words: aggressive non-Hodgkin lymphoma, chemotherapy, chemoimmunotherapy, supportive therapy.