https://doi.org/10.4081/hmr.v1i10.346

The microangiopathy of pregnancy

Vol. 1 No. 10: Hemostasis and pregnancy, Milan, November 10, 2005
Published: June 5, 2009
Abstract Views: 146
PDF: 296
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Armando D’Angelo
support@pagepress.org
Hypercoagulabilty occurs in uncomplicated pregnancies, beginning already during the first trimester of gestation. Fibrinogen and factor VIII levels show a progressive increase, accompanied during the second trimester by an increase in VWF levels, while factor XIII levels progressively decrease to 50% during the third trimester.1 This is consistent with increased in vivo thrombin generation and fibrin formation,2 leading to an increased antithrombin turnover.3 Protein S levels show major modifications, reaching 50% levels of normal at term.1 During pregnancy a condition of acquired protein C resistance is relatively common, due to the increase in factor VIII and V levels and, more important, to their increased state of activation.4,5 Global fibrinolytic activity is depressed until delivery, mainly due to increased levels of plasminogen activator inhibitors 1 and 2.1 Moderate thrombocytopenia occurs during the last stages of pregnancy and is mainly due to hemodilution.6

Dimensions

Altmetric

PlumX Metrics

Downloads

Citations

Crossref
Scopus
Google Scholar
Europe PMC

Supporting Agencies

How to Cite

D’Angelo, A. (2009). The microangiopathy of pregnancy. Hematology Meeting Reports (formerly Haematologica Reports), 1(10). https://doi.org/10.4081/hmr.v1i10.346
Authors who publish with this journal agree to the following terms: Authors retain copyright and grant the journal right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See The Effect of Open Access).