https://doi.org/10.4081/hmr.v1i8.287

Augmenting anti-tumor efficacy of adoptive immunotherapy with marrow infiltrating lymphocytes

Vol. 1 No. 8: New Drugs in Hematology, Bologna, October 9-11, 2005
Published: June 3, 2009
Abstract Views: 118
PDF: 170
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I Borrello
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Despite the ability to generate tumor-specific immunity in both murine and human models, the efficacy of immune-based therapeutic interventions has met with limited success. Effective immunotherapy requires: the precursor frequency of antigen specific T cells be present in sufficient numbers; T cell trafficking to the tumor site; and recognition and killing of their target upon antigen encounter. We have taken a step-wise approach in an effort to address these issues. We utilized a whole tumor cell approach in conjunction with a GM-CSF – producing bystander cell in an effort to prime an immune response towards a broad range of tumor antigens and simplify vaccine production.

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Borrello, I. (2009). Augmenting anti-tumor efficacy of adoptive immunotherapy with marrow infiltrating lymphocytes. Hematology Meeting Reports (formerly Haematologica Reports), 1(8). https://doi.org/10.4081/hmr.v1i8.287
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