CD30: a suitable target for immunotherapy?


https://doi.org/10.4081/hmr.v1i8.281
Vol. 1 No. 8: New Drugs in Hematology, Bologna, October 9-11, 2005
Published: May 29, 2009
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PDF: 436
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The CD30 antigen and its physiological function CD30 is a 120 kDa transmembrane glycoprotein belonging to the TNF-receptor superfamily and lacking an intracellular death domain. Physiologically, expression of CD30 is found on virus-infected lymphocytes and on a small subset of activated T cells. Furthermore this receptor is involved in the negative selection process of auto-reactive lymphocytes.1 The CD30 ligand (CD30L) is present on activated T cells, resting B cells, and granulocytes. As shown for most other members of the TNF-receptor family signaling via CD30 is pleiotropic and may result in different responses including apoptosis, differentiation and growth stimulation even in monoclonal cells. This response may depend on the developmental status and environment of the cell.2

Supporting Agencies


Borchmann, P. (2009). CD30: a suitable target for immunotherapy?. Hematology Meeting Reports (formerly Haematologica Reports), 1(8). https://doi.org/10.4081/hmr.v1i8.281
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