The use of purine analogues and infections

Published: May 29, 2009
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In the 1980s, the purine analogues chemotherapy agents, fludarabine, deoxycoformycin, chlorodeoxyadenosine, were introduced into clinical usage for the care of patients with a variety of hematologic malignancies. These drugs have been mainly used in indolent lymphoproliferative neoplasms with effective hematologic responses, but they have been accompanied by a different spectrum of infections because of selective T-cell abnormalities which these agents determine.

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Nosari, A. (2009). The use of purine analogues and infections. Hematology Meeting Reports (formerly Haematologica Reports), 1(5). https://doi.org/10.4081/hmr.v1i5.256