Chronic mucocutaneous candidiasis due to signal transducer and activator of transcription 1 mutation in a Saudi patient: a case report

Abdullah Alakeel; Khalid Nabil Nagshabandi; Abdulaziz Alsalhi

doi:10.4081/dr.2024.9939

Chronic mucocutaneous candidiasis (CMC) is a primary immunodeficiency condition caused by a genetic abnormality that increases the risk of recurrent and persistent skin, nail, and mucous membrane infections with Candida species, typically Candida albicans. Signal transducer and activator of transcription 1 (STAT1) gene mutation is a genetic trigger that causes CMC, which increases the risk of infections, multisystem disorders, and cancer susceptibility. We describe the first case of a Saudi female patient with clinical features of CMC with an underlying (STAT1) gene mutation.

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Alakeel , A., Nabil Nagshabandi, K., & Alsalhi, A. (2024). Chronic mucocutaneous candidiasis due to signal transducer and activator of transcription 1 mutation in a Saudi patient: a case report. Dermatology Reports, 16(4). https://doi.org/10.4081/dr.2024.9939