Radiation therapy in mycosis fungoides

Concetta Schiavone; Stefano Vagge; Filippo Grillo Ruggieri

doi:10.4081/dr.2024.9885

Radiation therapy in mycosis fungoides

https://doi.org/10.4081/dr.2024.9885

Smart Citations

Citing PublicationsSupportingMentioningContrasting

View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Captures

Readers: 1

Mentions

News Mentions: 1

see details

Authors

Concetta Schiavone
concetta.schiavone@galliera.it
Radiotherapy Unit, Galliera Hospital, Genoa, Italy. https://orcid.org/0009-0000-6826-3702
Stefano Vagge Radiotherapy Unit, Galliera Hospital, Genoa, Italy.
Filippo Grillo Ruggieri Radiotherapy Unit, Galliera Hospital, Genoa, Italy.

Radiation therapy (RT) is administered with varying intentions, sometimes even several times in the same or in different body areas, to over 50% of patients with neoplastic conditions. Numerous techniques are available to patients in the clinical evolution of mycosis fungoides (MF), and there are several indications for radiation therapy (RT). RT as a skin-directed therapy is very widely used in these patients, either alone or in conjunction with other therapies. The application of RT, a tried-and-true therapy that improves MF patients’ quality of life and treatment, can be encouraged by a multidisciplinary approach and an understanding of current methods and action mechanisms.

Kumari S, Mukherjee S, Sinha D, et al. Immunomodulatory effects of radiotherapy. Int J Mol Sci 2020; 21:8151. DOI: https://doi.org/10.3390/ijms21218151

Hoppe RT, Cox RS, Fuks Z, et al. Electron-beam therapy for mycosis fungoides: the Stanford University experience. Cancer Treat Rep 1979;63:691-700.

Lin SH, Ye R, Wang Y. Preclinical Strategies for Testing of Targeted Radiosensitizers. In: Willers, H., Eke, I. (eds.) Molecular targeted radiosensitizers. Cancer Drug Discovery and Development. Humana, Cham; 2020. DOI: https://doi.org/10.1007/978-3-030-49701-9_5

Kim E. Mogamulizumab for CTCL: targeted therapy and immunotherapy crossing paths. Dermatol World Insights Inquiries 2020;2.

Mukherjee S, Abdisalaam S, Bhattacharya S, et al. Mechanistic link between DNA damage sensing, repairing and signaling factors and immune signaling. Adv Protein Chem Struct Biol 2019;115:297-324. DOI: https://doi.org/10.1016/bs.apcsb.2018.11.004

Abdisalaam S, Bhattacharya S, Mukherjee S, et al. Dysfunctional telomeres trigger cellular senescence mediated by cyclic GMP-AMP synthase. J Biol Chem 2020;295:11144-60. DOI: https://doi.org/10.1074/jbc.RA120.012962

Deng L, Liang H, Xu M, et al. STING-dependent cytosolic DNA sensing promotes radiation-induced type I interferondependent antitumor immunity in immunogenic tumors. Immunity 2014;41:843-52. DOI: https://doi.org/10.1016/j.immuni.2014.10.019

Vanpouille-Box C, Alard A, Aryankalayil MJ, et al. DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity. Nat Commun 2017;8:15618. DOI: https://doi.org/10.1038/ncomms15618

Bhattacharya S, Srinivasan K, Abdisalaam S, Su, et al. RAD51 interconnects between DNA replication, DNA repair and immunity. Nucleic Acids Res 2017;45:4590-605. DOI: https://doi.org/10.1093/nar/gkx126

Mole RH. Whole body irradiation-radiobiology or medicine? Br J Radiol 1953;26:234-41. DOI: https://doi.org/10.1259/0007-1285-26-305-234

Nabrinsky W, Macklis J, Bitran J. A review of the abscopal effect in the era of immunotherapy. Cureus 2022;14:e29620. DOI: https://doi.org/10.7759/cureus.29620

Daguenet E, Louati S, Wozny AS, et al. Radiation-induced bystander and abscopal effects: important lessons from preclinical models. Br J Cancer 2020;123:339-48. DOI: https://doi.org/10.1038/s41416-020-0942-3

Son CH, Fleming GF, Moroney JW. Potential role of radiation therapy in augmenting the activity of immunotherapy for gynecologic cancers. Cancer Manag Res 217;9:553-63. DOI: https://doi.org/10.2147/CMAR.S116683

Frey B, Rückert M, Deloch L, et al. Immunomodulation by ionizing radiation-impact for design of radioimmunotherapies and for treatment of inflammatory diseases. Immunol Rev 2017;280:231-48. DOI: https://doi.org/10.1111/imr.12572

Jiang W, Chan CK, Weissman IL, et al. Immune priming of the tumor microenvironment by radiation. Trends Cancer 2016;2:638-45. DOI: https://doi.org/10.1016/j.trecan.2016.09.007

Trowell OA. The sensitivity of lymphocytes to ionizing radiation. J Pathol Bacteriol 1952;64:687-704. DOI: https://doi.org/10.1002/path.1700640403

Mazzeo E, Rubino L, Buglione M, et al. The current management of mycosis fungoides and Sézary syndrome and the role of radiotherapy: Principles and indications. Rep Pract Oncol Radiother 2013;19:77-91. DOI: https://doi.org/10.1016/j.rpor.2013.07.009

Montay-Gruel P, Bouchet A, Jaccard M, et al. X-rays can trigger the FLASH effect: ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice. Radiother Oncol 2018;129:582-8. DOI: https://doi.org/10.1016/j.radonc.2018.08.016

Bourhis J, Montay-Gruel P, Jorge PG, et al. Clinical translation of FLASH radiotherapy: Why and how? Radiother Oncol 2019;139:11-7. DOI: https://doi.org/10.1016/j.radonc.2019.04.008

Bourhis J, Sozzi WJ, Jorge PG, et al. Treatment of a first patient with FLASH-radiotherapy. Radiother Oncol 2019;139:18-22. DOI: https://doi.org/10.1016/j.radonc.2019.06.019

Favaudon V, Caplier L, Monceau V, et al. Ultrahigh dose-rate FLASH irradiation increases the differential response between normal and tumor tissue in mice. Sci Transl Med 2014;6. DOI: https://doi.org/10.1126/scitranslmed.3008973

Rahman M, Trigilio A, Franciosini G, et al. FLASH radiotherapy treatment planning and models for electron beams. Radiother Oncol 2022;175:210-21. DOI: https://doi.org/10.1016/j.radonc.2022.08.009

Scielzo G, Grillo Ruggieri F, Brunelli B, et al Physico-technical aspect of total skin irradiation with high intensity dose electrons. Radiol Med 1990;80:147-50.

Schiapparelli P, Zefiro D, Massone F, Taccini G. Total skin electron therapy (TSET): a reimplementation using radiochromic films and IAEA TSR-398 code of practice. Med Phys 2010;37. DOI: https://doi.org/10.1118/1.3442301

Page V, Gardner A, Karzmark CJ. Patient dosimetry in the electron treatment of large superficial lesions. Radiology 1970;94:635-41. DOI: https://doi.org/10.1148/94.3.635

Price NM, Hoppe RT, Constantine VS, et al. The treatment of mycosis fungoides: adjuvant topical mechlorethamine after electron beam therapy. Cancer 1977;40:2851-3. DOI: https://doi.org/10.1002/1097-0142(197712)40:6<2851::AID-CNCR2820400615>3.0.CO;2-X

Kudelka MR, Switchenko JM, Lechowicz MJ, et al. Maintenance therapy for cutaneous T-cell lymphoma after total skin electron irradiation: evidence for improved overall survival with ultraviolet therapy. Clin Lymphoma Myeloma Leuk 2020;20:757-67. DOI: https://doi.org/10.1016/j.clml.2020.06.020

Memorial Sloan Kettering Cancer Center. Protocol: 21-501. Available from: https://www.mskcc.org/cancer-care/clinicaltrials/21-501

Valli VB, Grillo Ruggieri F, Saporiti G, et al. Total skin electron beam therapy in patients with advanced cutaneous T cell lymphoma undergoing allogeneic stem cell transplantation: a single centre experience. Blood 2019;134:2042. DOI: https://doi.org/10.1182/blood-2019-131144

Schiavone, C., Vagge, S., & Grillo Ruggieri, F. (2024). Radiation therapy in mycosis fungoides. Dermatology Reports, 16(s2). https://doi.org/10.4081/dr.2024.9885