Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features


Published: 13 September 2023
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Authors

  • Francesco Savoia Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola (FC), Italy. https://orcid.org/0000-0001-8833-2453
  • Matelda Medri Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola (FC), Italy.
  • Davide Melandri Dermatology Unit, Bufalini Hospital, AUSL della Romagna, Cesena (FC); Dermatology Unit, IRCCS Azienda Ospedaliero-Universitaria di Bologna; Department of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Italy.
  • Lucia Domeniconi Pathologic Anatomy, AUSL della Romagna, Ravenna, Italy.
  • Emilia Crisanti Pathologic Anatomy, AUSL della Romagna, Ravenna, Italy.
  • Andrea Sechi Dermatology Unit, San Bortolo Hospital, Vicenza, Italy. https://orcid.org/0000-0003-3026-2434
  • Ignazio Stanganelli Skin Cancer Unit, IRCCS Istituto Romagnolo per lo Studio dei Tumori (IRST) “Dino Amadori”, Meldola (FC); Dermatology Unit, Department of Clinical and Experimental Medicine, University of Parma, Italy.

Cutaneous sebaceous carcinoma (CSC) can be classified into periocular and extraocular and can occur as part of Muir-Torre syndrome. It is usually a pink-red or yellow solitary nodule, mainly located in the head and neck region. According to the literature, dermoscopy is characterized in most cases by a yellow color, polymorphic vessels, and ulceration. We performed a review of the literature, and we found 14 papers describing the dermoscopic features of 33 sebaceous carcinomas, to which we added a case that we have recently observed. Compared to the data of the literature and in particular to the latest published reviews, we found that milky-red areas are frequently observed in CSC (47% of the cases) and can be added to the main dermoscopic features for the diagnosis. In our case, histology showed some features that were consistent with a CSC with a secretory pattern, and other features that were instead consistent with a non-secretory pattern. This was probably due to the fact that the lesion we observed was a moderately differentiated and not well-differentiated CSC. The presence of a CSC should always alert the clinician to the possible association with Muir-Torre syndrome, and immunohistochemistry for mismatch repair gene defects can help in the diagnostic pathway.


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Savoia, F., Medri, M., Melandri, D., Domeniconi, L., Crisanti, E., Sechi, A., & Stanganelli, I. (2023). Extraocular cutaneous sebaceous carcinoma in a patient with Muir-Torre syndrome: special emphasis on histologic and dermoscopic features. Dermatology Reports, 16(3). https://doi.org/10.4081/dr.2023.9832

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