Klinefelter syndrome and cutaneous localization of diffuse large B cell lymphoma: a real connection or a casual association?


Published: 29 August 2023
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Authors

  • Federica Scarfì Dermatology Unit, Toscana Centro Local Health Unit, Prato Hospital; Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
  • Elisabetta Magnaterra Dermatology Unit, Toscana Centro Local Health Unit, Prato Hospital; Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
  • Simone Santini Hematology and Oncohematology Unit, Toscana Centro Local Health Unit, Prato Hospital, Italy.
  • Franca Taviti Dermatology Unit, Toscana Centro Local Health Unit, Prato Hospital, Italy.

Diffuse large B cell lymphoma (DLBCL) is a common aggressive subtype of non-Hodgkin lymphoma, accounting for nearly 30-40% of all cases. This condition can affect the skin both primarily and secondarily. Herein we report a clinical and dermoscopic case of skin metastasis of DLBCL in a patient with Klinefelter syndrome.


Swerdlow SH, Campo E, Pileri SA, et al. The 2016 revision of the World Health Organization classification of lymphoid neoplasms. Blood 2016;127:2375-90. DOI: https://doi.org/10.1182/blood-2016-01-643569

Li S, Young KH, Medeiros LJ. Diffuse large B-cell lymphoma. Pathology 2018;50:74-87. DOI: https://doi.org/10.1016/j.pathol.2017.09.006

Lanfranco F, Kamischke A, Zitzmann M, Nieschlag E. Klinefelter's syndrome. Lancet 2004;364:273-83. DOI: https://doi.org/10.1016/S0140-6736(04)16678-6

Kanakis GA, Nieschlag E. Klinefelter syndrome: more than hypogonadism. Metabolism 2018;86:135-44. DOI: https://doi.org/10.1016/j.metabol.2017.09.017

Rojas AP, Vo DV, Mwangi L, et al. Oncologic manifestations of Klinefelter syndrome. Hormones 2020;19:497-504. DOI: https://doi.org/10.1007/s42000-020-00241-7

De Sanctis V, Fiscina B, Soliman A, et al. Klinefelter syndrome and cancer: from childhood to adulthood. Pediatr Endocrinol Rev 2013;11:44-50.

Swerdlow AJ, Schoemaker MJ, Higgins CD, et al. Cancer incidence and mortality in men with Klinefelter syndrome: a cohort study. J Natl Cancer Inst 2005;97:1204-10. DOI: https://doi.org/10.1093/jnci/dji240

Ji J, Zöller B, Sundquist J, Sundquist K. Risk of solid tumors and hematological malignancy in persons with Turner and Klinefelter syndromes: a national cohort study. Int J Cancer 2016;139:754-8. DOI: https://doi.org/10.1002/ijc.30126

Hayashi Y, Eguchi M, Sugita K, et al. Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome. Blood 1988;72:15-23. DOI: https://doi.org/10.1182/blood.V72.1.15.bloodjournal72115

Errichetti E, Geller S, Zalaudek I, et al. Dermatoscopy of nodular/plaque-type primary cutaneous T- and B-cell lymphomas: a retrospective comparative study with pseudolymphomas and tumoral/inflammatory mimickers by the International Dermoscopy Society. J Am Acad Dermatol 2022;86:774-81. DOI: https://doi.org/10.1016/j.jaad.2021.10.020

Sławińska M, Sokołowska-Wojdyło M, Olszewska B, et al. Dermoscopic and trichoscopic features of primary cutaneous lymphomas - systematic review. J Eur Acad Dermatol Venereol 2021;35:1470-84. DOI: https://doi.org/10.1111/jdv.17219

Scarfì, F., Magnaterra, E., Santini, S., & Taviti, F. (2023). Klinefelter syndrome and cutaneous localization of diffuse large B cell lymphoma: a real connection or a casual association?. Dermatology Reports, 16(3). https://doi.org/10.4081/dr.2023.9812

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