Exploring adult-onset actinic prurigo in Thailand
https://doi.org/10.4081/dr.2023.9810
HTML: 22
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Actinic prurigo (AP) is an uncommon photodermatosis. In European and Native American populations, AP is more common in young women and demonstrates clinical improvement or remission in adulthood. The clinical signs of AP differ in Asians because the disorder typically occurs in adults (adult-onset AP) and is clinically persistent. The objective of this study was to investigate the characteristics and outcomes of patients with AP in Thailand. A total of 15 cases with AP were evaluated. All of them were adultonset AP (mean onset age of 45.5 years). Males predominated (66.7%). The majority of them manifested with papules on the face and upper extremities. Mucositis was present in 2 patients. Phototesting revealed that the minimal erythematous dose (MED) for UVA decreased in 3 subjects and the MED for both UVA and UVB decreased in other 3 patients. A photo-provocation test was performed on 9 patients with normal MED, and 5 of them showed positive UVA photo-provocation, while 4 showed positive UVA and UVB photop-rovocation. A systemic immunosuppressant was prescribed in 60% of patients. Median time for clinical improvement was 8.6 months. Complete clinical remission was found in only 3 patients. Adult-onset AP has different clinical features and responds differently to treatment, compared to classical AP.
Menagé Hd, Vaughan RW, Baker CS, et al. HLA-DR4 may determine expression of actinic prurigo in British patients. J Invest Dermatol 1996;106:362-7. DOI: https://doi.org/10.1111/1523-1747.ep12343141
Lane PR, Hogan DJ, Martel MJ, et al. Actinic prurigo: clinical features and prognosis. J Am Acad Dermatol 1992;26:683-92. DOI: https://doi.org/10.1016/0190-9622(92)70093-U
Chen YA, Yang CC, Ting SW, et al. Adult-onset actinic prurigo: report of 19 patients from Taiwan. J Eur Acad Dermatol Venereol 2016;30:e140-e2. DOI: https://doi.org/10.1111/jdv.13450
Akaraphanth R, Sindhavananda J, Gritiyarangsan P. Adult-onset actinic prurigo in Thailand. Photodermatol Photoimmunol Photomed 2007;23:234-7. DOI: https://doi.org/10.1111/j.1600-0781.2007.00316.x
Bernal JE, Duran de Rueda MM, Ordonez CP, et al. Actinic prurigo among the Chimila Indians in Colombia: HLA studies. J Am Acad Dermatol 1990;22:1049-51. DOI: https://doi.org/10.1016/0190-9622(90)70150-G
Cuevas-Gonzalez JC, Vega-Memíje ME, Borges-Yáñez SA, Rodríguez-Lobato E. Risk factors associated with actinic prurigo: a case control study. An Bras Dermatol 2017;92:774-8. DOI: https://doi.org/10.1590/abd1806-4841.20175105
Ker KJ, Chong WS, Theng CT. Clinical characteristics of adult-onset actinic prurigo in Asians: a case series. Indian J Dermatol Venereol Leprol 2013;79:783-8. DOI: https://doi.org/10.4103/0378-6323.120726
Macfarlane L, Hawkey S, Naasan H, Ibbotson S. Characteristics of actinic prurigo in Scotland: 24 cases seen between 2001 and 2015. Br J Dermatol 2016;174:1411-4. DOI: https://doi.org/10.1111/bjd.14444
Wiseman MC, Orr PH, Macdonald SM, et al. Actinic prurigo: clinical features and HLA associations in a Canadian Inuit population. J Am Acad Dermatol 2001;44:952-6. DOI: https://doi.org/10.1067/mjd.2001.112579
Plaza JA, Toussaint S, Prieto VG, et al. Actinic prurigo cheilitis: a clinicopathologic review of 75 cases. Am J Dermatopathol 2016;38:418-22. DOI: https://doi.org/10.1097/DAD.0000000000000459
Copyright (c) 2023 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
