Combination of cyclosporine A and methylprednisolone to treat pediatric Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome
https://doi.org/10.4081/dr.2023.9656
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Authors
- Shinta Trilaksmi Dewi Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. https://orcid.org/0000-0001-8972-4379
- Laily Noor Qomariah Wates Government District Hospital, Kulon Progo, Yogyakarta, Indonesia.
- Widya Khairunisa Sarkowi Faculty of Medicine, IPB University, Bogor, West Java, Indonesia. https://orcid.org/0000-0002-3974-5371
- Monika Puspitasari Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
- Miya Khalidah Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. https://orcid.org/0000-0001-5730-9306
- Marcella Anggatama Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
- Dwinanda Almira Rizkiani Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia. https://orcid.org/0000-0003-3172-1962
- Kristiana Etnawati Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
- Sri Awalia Febriana Department of Dermatology and Venereology, Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia.
The treatment of epidermal necrolysis in pediatric patients remains a major challenge. Cyclosporine A has emerged as a promising therapy for epidermal necrolysis in adults; however, its efficacy in children is unclear. We present the case of a boy with Stevens-Johnson syndrome/toxic epidermal necrolysis overlap syndrome who was initially resistant to methylprednisolone monotherapy but improved after receiving the combination of cyclosporine A and methylprednisolone. Published reports on the use of cyclosporine A for pediatric epidermal necrolysis are also briefly reviewed.
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