Cicatricial alopecia associated with pemphigus


Published: 14 June 2023
Abstract Views: 416
PDF: 274
HTML: 9
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Pemphigus is a chronic autoimmune bullous disease associated with the production of autoantibodies directed against desmosomal proteins, such as desmogleins 1 and 3. Here, we present the case of an 83-year-old woman who was referred to us with suspicious cicatricial alopecia of the scalp and a small, eroded lesion on the forehead, previously labeled as atrophic actinic keratosis after a skin biopsy. In our clinic, after a careful examination of the case, we decided to perform two new skin biopsies of the scalp on suspicion of an inflammatory disease.


Schmidt E, Kasperkiewicz M, Joly P. Pemphigus. Lancet 2019;394:882-94.

Reis Gavazzoni Dias MF, Aparecida Guedes Vilar E, de Oliveira Bento C, et al. Brunsting-Perry type pemphigoid causing secondary cicatricial alopecia in 2 patients. Skin Appendage Disord 2018;4:308-11.

Daneshpazhooh M, Fatehnejad M, Rahbar Z, et al. Trauma-induced pemphigus: a case series of 36 patients. J Dtsch Dermatol Ges 2016;14:166-71.

Daneshpazhooh M, Mahmoudi HR, Rezakhani S, et al. Loss of normal anagen hair in pemphigus vulgaris. Clin Exp Dermatol 2015;40:485-8.

Jappe U, Schröder K, Zillikens D, Petzoldt D. Tufted hair folliculitis associated with pemphigus vulgaris. J Eur Acad Dermatol Venereol 2003;17:223-6.

Veraitch O, Ohyama M, Yamagami J, Amagai M. Alopecia as a rare but distinct manifestation of pemphigus vulgaris. J Eur Acad Dermatol Venereol 2013;27:86-91.

Esmaili N, Chams-Davatchi C, Valikhani M, et al. Pemphigus vulgaris in Iran: a clinical study of 140 cases. Int J Dermatol 2007;46:1166-70.

Sar-Pomian M, Rudnicka L, Olszewska M. The significance of scalp involvement in pemphigus: a literature review. Biomed Res Int 2018;2018:6154397.

Sar-Pomian M, Czuwara J, Rudnicka L, Olszewska M. Increased risk of severe course of pemphigus in patients with pemphigus-associated alopecia: a prospective observational study. Clin Exp Dermatol 2019;44:e73-e80.

Wu H, Stanley JR, Cotsarelis G. Desmoglein isotype expression in the hair follicle and its cysts correlates with type of keratinization and degree of differentiation. J Invest Dermatol 2003;120:1052-7. Erratum in: J Invest Dermatol 2003;121:434.

Koch PJ, Mahoney MG, Cotsarelis G, et al. Desmoglein 3 anchors telogen hair in the follicle. J Cell Sci 1998;111:2529-37.

Aromolo IF, Maronese CA, Moltrasio C, et al. Brunsting-Perry pemphigoid: a systematic review. Int J Dermatol 2022;61:1353-8.

D’Astolto, R., Zangrando, C., & Feliciani, C. (2023). Cicatricial alopecia associated with pemphigus. Dermatology Reports, 15(3). https://doi.org/10.4081/dr.2023.9653

Downloads

Download data is not yet available.

Citations