Lupus panniculitis: a rare bilateral and symmetrical manifestation of cutaneous lupus erythematosus in an adolescent girl
https://doi.org/10.4081/dr.2022.9515
Accepted: 16 May 2022
HTML: 119
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Lupus panniculitis is included in the chronic cutaneous lupus erythematosus group. An 18-year-old female patient came with the complaint of lumps on her face. When she was 16 years old, the patient started to complain about lumps on her right lower arm. Lumps were observed on her left cheek and right chin during the ongoing treatment. Histopathology results showed lymphocyte infiltration in between lobular adipocyte with fibrotic and fat necrosis in the subcutis. Lupus panniculitis lesions in this patient were found both on her face and on her lower arms, which are not considered common predilection sites of lupus panniculitis. The skin lesion observed in this patient was also bilateral and symmetrical, which was a rare finding.
Kang S, Amagai M, Bruckner AL, et al. Fitzpatrick's Dermatology in General Medicine. 9th ed. New York: McGraw-Hill Education; 2019.
Burns T, Breathnach S, Cox N, Griffiths C, eds. Rook's Textbook of Dermatology. Vol 1. Chichester: Wiley-Blackwell; 2010.
Thiruveedhula H, Kurapati A, Samanthula H, Bora MKR. Bilaterally symmetrical lupus profundus with livedo reticularis as a sole cutaneous manifestation in a case of systemic lupus erythematosus. Int J Res Dermatol 2020;6:795-7.
McCarty M, Jeffries M, Hansen R. Lupus erythematosus profundus presenting as morphea-like lesions involving bilateral malar areas of a 12-year-old Philippine male with a negative ANA. J Am Acad Dermatol 2011;64.
Massone C, Kodama K, Salmhofer W, et al. Lupus erythematosus panniculitis (lupus profundus): clinical, histopathological, and molecular analysis of nine cases. J Cutan Pathol 2005;32:396-404.
Kopp A, Buechler C, Neumeier M, et al. Innate immunity and adipocyte function: ligand-specific activation of multiple toll-like receptors modulates cytokine, adipokine, and chemokine secretion in adipocytes. Obesity 2009;17:648-56.
Kono DH, Haraldsson MK, Lawson BR, et al. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proce Natl Acad Sci U S A 2009;106:12061-6.
Lafyatis R, York M, Marshak-Rothstein A. Antimalarial agents: closing the gate on toll-like receptors? Arthritis Rheum 2006;54:3068-70.
Barrat FJ, Coffman RL. Development of TLR inhibitors for the treatment of autoimmune diseases. Immunol Rev 2008;223:271-83.
Eastham AB, Liang CA, Femia AN, et al. Lupus erythematosus panniculitis–induced facial atrophy: effective treatment with poly-L-lactic acid and hyaluronic acid dermal fillers. J Am Acad Dermatol 2013;69:e260-2.
Vera-Lastra O, Medina G, Cruz-Dominguez MdP, et al. Human adjuvant disease induced by foreign substances: a new model of ASIA (Shoenfeld's syndrome). Lupus 2012;21:128-35.
Gupta K, Bhari N, Verma KK, Gupta S. Permanent injectable polyacrylamide hydrogel dermal filler for a large subcutaneous defect secondary to lupus panniculitis. Dermatol Surg 2017;43:152-4.
Lei H, Ma GE, Liu Z. Evaluation of repairing facial depression deformities secondary to lupus erythematosus panniculitis with autologous fat grafting. J Craniofac Surg 2016;27:1765-9.
Copyright (c) 2022 the Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Downloads
Citations
