Leser-Trélat sign as a rare manifestation of cutaneous melanoma
https://doi.org/10.4081/dr.2020.8665
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Leser-Trélat Sign (LTS) is a rare paraneoplastic syndrome characterized by the sudden eruption of multiple seborrheic keratoses in patients with internal malignancy, commonly localized in the gastrointestinal tract. We report an 80-year-old female patient showing a rapid increase in the number and size of seborrheic keratosis associated with the diagnosis of a cutaneous nodular melanoma (Breslow thickness: 4.5 mm) located on the right flank. After the excision of melanoma, subsequent staging procedures resulted negative, moreover no evidence of melanoma recurrence and no changes of the seborrheic keratoses was detected after a follow-up of 52 months. Although the association between melanoma and Leser Trelat sign is rare, an accurate skin examination with the aid of dermatoscopy searching for undiagnosed skin cancers, should be suggested in patient with sudden eruption of keratosis seborrheic to early diagnose and treat a possible melanoma.
2. Wollina U. Recent advances in managing and understanding seborrheic keratosis. F1000Res. 2019 28;8. pii: F1000 Faculty Rev-1520.
3. Silva JA, Mesquita Kde C, Igreja AC, Lucas IC, Freitas AF, Oliveira SM, Costa IM, Campbell IT. Paraneoplastic cutaneous manifestations: concepts and updates. An Bras Dermatol. 2013;88(1):9-22.
4. Ellis DL, Kafka SP, Chow JC at al. Melanoma, growth factors, acanthosis nigricans, the sign of Leser-Trélat, and multiple acrochordons. A possible role for alpha-transforming growth factor in cutaneous paraneoplastic syndromes. N Engl J Med. 1987;317(25):1582-7.
5. Fanti PA, Metri M, Patrizi A. The sign of Leser-Trélat associated with malignant melanoma. Cutis. 1989;44(1):39-41.
6. Siedek V, Schuh T, Wollenberg A. Leser-Trelat sign in metastasized malignant melanoma. Eur Arch Otorhinolaryngol. 2009;266(2):297-9.
7. Pereira R, Carvalho SD, Cruz JF. Leser-Trélat sign in metastatic melanoma to pleura. BMJ Case Rep. 2019 (3);12(4).
8. Chaudhary S, Bansal C, Husain A. Literature meta-analysis of zosteriform cutaneous metastases from melanoma and a clinico-histopathological report from India. Ecancermedicalscience. 2013;7:324.
9. Carrera C, Segura S, Aguilera P, et al. Dermoscopy Improves the Diagnostic Accuracy of Melanomas Clinically Resembling Seborrheic Keratosis: Cross-Sectional Study of the Ability to Detect Seborrheic Keratosis-Like Melanomas by a Group of Dermatologists with Varying Degrees of Experience. Dermatology. 2017;233(6):471–479.
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