Bullous Pemphigoid with secondary Acquired Reactive Perforating Collagenosis: a challenging clinical case report

Valentina Ruffo di Calabria; Elena Biancamaria Mariotti; Alberto Corrà; Alice Verdelli; Lavinia Quintarelli; Cristina Aimo; Giovanni Di Zenzo; Vincenza Maio; Daniela Massi; Marzia Caproni

doi:10.4081/dr.2024.10087

Authors

Valentina Ruffo di Calabria
valentina.ruffodicalabria@unifi.it
Section of Dermatology, Department of Health Sciences, University of Florence, Italy. https://orcid.org/0000-0003-0307-6636
Elena Biancamaria Mariotti Section of Dermatology, Department of Health Sciences, University of Florence, Italy. https://orcid.org/0000-0003-0388-1037
Alberto Corrà Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Alice Verdelli Rare Skin Diseases Unit, P.O. Piero Palagi, Azienda USL Toscana Centro, ERN-SKIN Member, Department of Health Sciences, University of Florence, Italy.
Lavinia Quintarelli Rare Skin Diseases Unit, P.O. Piero Palagi, Azienda USL Toscana Centro, ERN-SKIN Member, Department of Health Sciences, University of Florence, Italy. https://orcid.org/0000-0002-9228-8042
Cristina Aimo Section of Dermatology, Department of Health Sciences, University of Florence, Italy.
Giovanni Di Zenzo Molecular and Cell Biology Laboratory, IDI-IRCCS, Rome, Italy. https://orcid.org/0000-0001-6106-599X
Vincenza Maio Section of Anatomic Pathology, Azienda USL Toscana Centro, Florence, Italy.
Daniela Massi Section of Anatomic Pathology, Department of Health Sciences, University of Florence, Italy. https://orcid.org/0000-0002-5688-5923
Marzia Caproni Rare Skin Diseases Unit, P.O. Piero Palagi, Azienda USL Toscana Centro, ERN-SKIN Member, Department of Health Sciences, University of Florence, Italy. https://orcid.org/0000-0002-7471-3471

Bullous Pemphigoid (BP) is a common autoimmune blistering disorder with unknown aetiology. During the last decades, its association with various common comorbidities, including cardiovascular, metabolic, neuropsychiatric, and neoplastic disorders, has been established. However, in recent years an increasing number of BP cases have also been reported in association with rarer diseases, including Acquired Reactive Perforating Collagenosis (ARPC). Patients with coexisting BP and ARPC have been reported to share common clinical features including metabolic comorbidities e.g., Diabetes Mellitus (DM). As the evolution from ARPC cutaneous involvement to classic BP lesions has been more frequently described, it has been suggested that it may represent a new clinical variant of BP with a specific pathogenetic background. Here is reported a challenging case in which a typical onset of BP was later followed by the eruption of atypical ARPC lesions in a patient with multiple non-compensated metabolic and cardiovascular comorbidities.

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Ruffo di Calabria, V., Mariotti , E. B., Corrà, A., Verdelli, A., Quintarelli, L., Aimo, C., Di Zenzo, G., Maio, V., Massi, D., & Caproni, M. (2024). Bullous Pemphigoid with secondary Acquired Reactive Perforating Collagenosis: a challenging clinical case report. Dermatology Reports. https://doi.org/10.4081/dr.2024.10087