Multimorbidity in adult patients diagnosed with atopic dermatitis
Accepted: 31 August 2024
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Atopic dermatitis (AD) may be associated with other diseases, which could impact the patient's overall health. The aim of this study was to assess the comorbidities observed in patients diagnosed with AD and psoriasis compared to healthy patients. Patients over 18 years old were recruited using the medical databases of dermatology clinics. Initially, 378 patients were selected via an analysis of the ICD-10 codes. Ultimately, 231 patients with atopic dermatitis were included in the study group based on their fulfillment of the Hanifin and Rajka criteria. They included 104 women and 127 men with an age range of 18-62. In patients with AD, selected lifestyle diseases such as obesity and atherosclerosis occurred significantly less frequently than in patients without AD, including those with other dermatoses. In addition, allergic asthma and type 2 diabetes occurred significantly more often in AD patients than in those without AD (p<0.05). In some AD patients, comorbidities are more prevalent, and these are often associated with allergic asthma and type 2 diabetes.
Spergel JM. From atopic dermatitis to asthma: the atopic march. Ann Allergy Asthma Immunol 2010;105:99-106; quiz 107-9,117. DOI: https://doi.org/10.1016/j.anai.2009.10.002
Dharmage SC, Lowe AJ, Matheson MC, et al. Atopic dermatitis and the atopic march revisited. Allergy 2014;69:17-27. DOI: https://doi.org/10.1111/all.12268
Guttman-Yassky E, Krueger JG, Lebwohl MG. Systemic immune mechanisms in atopic dermatitis and psoriasis with implications for treatment. Exp Dermatol 2018;27:409-17. DOI: https://doi.org/10.1111/exd.13336
Zhang A, Silverberg JI. Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. J Am Acad Dermatol 2015;72:606-16.e4. DOI: https://doi.org/10.1016/j.jaad.2014.12.013
Silverberg JI, Becker L, Kwasny M, et al. Central obesity and high blood pressure in pediatric patients with atopic dermatitis. JAMA Dermatol 2015;151:144-52. DOI: https://doi.org/10.1001/jamadermatol.2014.3059
Silverberg JI, Silverberg NB, Lee-Wong M. Association between atopic dermatitis and obesity in adulthood. Br J Dermatol 2012;166:498-504. DOI: https://doi.org/10.1111/j.1365-2133.2011.10694.x
Ascott A, Mulick A, Yu AM, et al. Atopic eczema and major cardiovascular outcomes: a systematic review and meta-analysis of population-based studies. J Allergy Clin Immunol 2019;143:1821-9. DOI: https://doi.org/10.1016/j.jaci.2018.11.030
Yousaf M, Ayasse M, Ahmed A, et al. Association between atopic dermatitis and hypertension: a systematic review and meta-analysis. Br J Dermatol 2022;186:227-35. DOI: https://doi.org/10.1111/bjd.20661
Amber T, Tabassum S. Cyclosporin in dermatology: a practical compendium. Dermatol Ther 2020;33:e13934. DOI: https://doi.org/10.1111/dth.13934
Yaneva M, Darlenski R. The link between atopic dermatitis and asthma- immunological imbalance and beyond. Asthma Res Pract 2021;7:16. DOI: https://doi.org/10.1186/s40733-021-00082-0
Li H, Dai T, Liu C, et al. Phenotypes of atopic dermatitis and the risk for subsequent asthma: a systematic review and meta-analysis. J Am Acad Dermatol 2022;86:365-72. DOI: https://doi.org/10.1016/j.jaad.2021.07.064
Ravnborg N, Ambikaibalan D, Agnihotri G, et al. Prevalence of asthma in patients with atopic dermatitis: a systematic review and meta-analysis. J Am Acad Dermatol 2021;84:471-8. DOI: https://doi.org/10.1016/j.jaad.2020.02.055
Mirghani HO, Alhazmi K, Alghamdi S, et al. The cross-talk between atopic dermatitis and diabetes mellitus: a meta-analysis. Cureus 2021;13:e13750. DOI: https://doi.org/10.7759/cureus.13750
Lee SW, Park J, Kim H, et al. Risk of type 2 diabetes mellitus in adult patients with atopic dermatitis. Diabetes Res Clin Pract 2023;204:110883. DOI: https://doi.org/10.1016/j.diabres.2023.110883
Lu F, Wu B, Wang Y. Mendelian randomization indicates that atopic dermatitis contributes to the occurrence of diabetes. BMC Med Genomics 2023;16:132. DOI: https://doi.org/10.1186/s12920-023-01575-y
Andersen YMF, Egeberg A, Gislason GH, et al. Adult atopic dermatitis and the risk of type 2 diabetes. J Allergy Clin Immunol 2017;139:1057-9. DOI: https://doi.org/10.1016/j.jaci.2016.08.049
Gonzalez-Uribe V, Cruz HVDL, Gomez-Nuñez A, et al. Comorbidities & burden of disease in atopic dermatitis. Asian Pac J Allergy Immunol 2023;41:97-105.
Thyssen JP, Halling-Overgaard AS, Andersen YMF, et al. The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis. Br J Dermatol 2018;178:1272-9. DOI: https://doi.org/10.1111/bjd.16215
Carrascosa JM, Morillas-Lahuerta V. Comorbidities in atopic dermatitis: an update and review of controversies. Actas Dermosifiliogr (Engl Ed) 2020;111:481-6. DOI: https://doi.org/10.1016/j.adengl.2020.04.012
Thyssen JP, Egeberg A. Cardiovascular disease and atopic dermatitis: epidemiological strengths and limitations. Br J Dermatol 2018;179:1014-5. DOI: https://doi.org/10.1111/bjd.16939
Thyssen JP, Halling AS, Schmid-Grendelmeier P, et al. Comorbidities of atopic dermatitis-what does the evidence say? J Allergy Clin Immunol 2023;151:1155-62. DOI: https://doi.org/10.1016/j.jaci.2022.12.002
Egeberg A, Andersen YM, Gislason GH, et al. Prevalence of comorbidity and associated risk factors in adults with atopic dermatitis. Allergy 2017;72:783-91. DOI: https://doi.org/10.1111/all.13085
Sybilski AJ, Raciborski F, Lipiec A, et al. Epidemiology of atopic dermatitis in Poland according to the epidemiology of allergic disorders in Poland (ECAP) study. J Dermatol 2015;42:140-7. DOI: https://doi.org/10.1111/1346-8138.12731
Paller AS, Spergel JM, Mina-Osorio P, et al. The atopic march and atopic multimorbidity: many trajectories, many pathways. J Allergy Clin Immunol 2019;143:46-55. DOI: https://doi.org/10.1016/j.jaci.2018.11.006
Amat F, Soria A, Tallon P, et al. New insights into the phenotypes of atopic dermatitis linked with allergies and asthma in children: an overview. Clin Exp Allergy 2018;48:919-34. DOI: https://doi.org/10.1111/cea.13156
Hogan MB, Peele K, Wilson NW. Skin barrier function and its importance at the start of the atopic march. J Allergy (Cairo) 2012;2012:901940. DOI: https://doi.org/10.1155/2012/901940
Wu CY, Lu YY, Lu CC, et al. Osteoporosis in adult patients with atopic dermatitis: a nationwide population-based study. PLoS One 2017;12:e0171667. DOI: https://doi.org/10.1371/journal.pone.0171667
Shaheen MS, Silverberg JI. Atopic dermatitis is associated with osteoporosis and osteopenia in older adults. J Am Acad Dermatol 2019;80:550-1. DOI: https://doi.org/10.1016/j.jaad.2018.05.026
Skaaby T, Husemoen LLN, Roswall N, et al. Atopy and development of cancer: a population-based prospective study. J Allergy Clin Immunol Pract 2014;2:779-85. DOI: https://doi.org/10.1016/j.jaip.2014.06.010
Halling-Overgaard AS, Ravnborg N, Silverberg JI, et al. Atopic dermatitis and cancer in solid organs: a systematic review and meta-analysis. J Eur Acad Dermatol Venereol 2019;33:e81-2. DOI: https://doi.org/10.1111/jdv.15230
Das P, Mounika P, Yellurkar ML, et al. Keratinocytes: an enigmatic factor in atopic dermatitis. Cells 2022;11:1683. DOI: https://doi.org/10.3390/cells11101683
Rønnstad ATM, Halling-Overgaard AS, Hamann CR, et al. Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: a systematic review and meta-analysis. J Am Acad Dermatol 2018;79:448-56.e30. DOI: https://doi.org/10.1016/j.jaad.2018.03.017
Patel KR, Immaneni S, Singam V, et al. Association between atopic dermatitis, depression, and suicidal ideation: a systematic review and meta-analysis. J Am Acad Dermatol 2019;80:402-10. DOI: https://doi.org/10.1016/j.jaad.2018.08.063
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