Lichen Planus Pigmentosus Inversus: case report and systematic review
Accepted: 31 August 2024
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Lichen Planus Pigmentosus Inversus (LPPI) is a rare variant of lichen planus characterized by well-demarcated, often slight pruritic, dark-gray plaques in intertriginous zones, hence the attribute of “inversus”, originally described by Pock et al. in 2001. Less than 100 cases have been reported to date, and here we present a case in a 52-year-old male who presented with two months duration of grey-brownish plaques in bilateral axillary, submammary, antecubital, and inguinal folds. No triggering agent was present, and the biopsy showed an interface/lichenoid dermatitis with plenty of pigment incontinence. Topical tacrolimus 0.1% ointment was administered with moderate improvement at five weeks. A review of the literature showed no significant differences in involved sites and age distribution among genders, with a slightly longer duration of manifestations in females. The most administered therapeutic agents were topical corticosteroids, alone or in combination with other agents, and tacrolimus.
Pock L, Jelínková L, Drlík L, et al. Lichen planus pigmentosus-inversus. J Eur Acad Dermatol Venereol. 2001;15:452-4. DOI: https://doi.org/10.1046/j.1468-3083.2001.00347.x
Bennàssar A, Mas A, Julià M, et al. Annular plaques in the skin folds: 4 cases of lichen planus pigmentosus-inversus. Actas Dermosifiliogr. 2009;100:602-5. DOI: https://doi.org/10.1016/S1578-2190(09)70128-3
Ohshima N, Shirai A, Saito I, Asahina A. Lichen planus pigmentosus-inversus occurring extensively in multiple intertriginous areas. The Journal of Dermatology. 2012;39:412-4. DOI: https://doi.org/10.1111/j.1346-8138.2011.01283.x
Barros HR, Almeida JRP de, Mattos e Dinato SL, et al. Lichen planus pigmentosus inversus. An Bras Dermatol. 2013;88:146-9. DOI: https://doi.org/10.1590/abd1806-4841.20132599
Robles-Méndez JC, Rizo-Frías P, Herz-Ruelas ME, et al. Lichen planus pigmentosus and its variants: review and update. Int J Dermatol. 2018;57:505-14. DOI: https://doi.org/10.1111/ijd.13806
Lamberti A, Falcinelli F, Cinotti E, et al. Unilateral lichen planus pigmentosus inversus: Line‐field confocal optical coherence tomography features and histopathological correlation. J Eur Acad Dermatology Venereol. 2024;38:e799-801. DOI: https://doi.org/10.1111/jdv.19914
Edek YC, Tamer F, Öğüt B. Lichen planus pigmentosus inversus with nail involvement following COVID-19 vaccination: A case report. Dermatologic Therapy. 2022;35:e15809. DOI: https://doi.org/10.1111/dth.15809
Sun L, Duarte S, Soares-de-Almeida L. Case of lichen planus pigmentosus-inversus after Oxford-AstraZeneca COVID-19 vaccine: cause or coincidence? Journal of the European Academy of Dermatology and Venereology : JEADV. 2022;36:e514-6. DOI: https://doi.org/10.1111/jdv.18058
Gil-Quiñones SR, Velandia JA, Velandia F, Barrera MY. Lichen planus and lichen planus pigmentosus inversus following COVID-19 vaccine in dark phototype patients. Actas dermo-sifiliograficas. Spain; 2024;115:609-11. DOI: https://doi.org/10.1016/j.ad.2023.02.005
Roster K, Tarawneh OH, Zufall A, et al. Dermatoscopic rainbow pattern in lichen planus pigmentosus inversus in a middle-aged African American man. JAAD Case Reports. 2023;35:118-21. DOI: https://doi.org/10.1016/j.jdcr.2023.03.014
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