https://doi.org/10.4081/ar.2010.e2

IGF-1: a marker of individual life-span in a primate

Vol. 1 No. 1 (2010)
Submitted: 27 November 2009
Accepted: 14 March 2010
Published: 24 March 2010
IGF-1, marker of longevity, primates
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Authors

Fabienne Aujard
Marie Thérèse Bluet-Pajot
Philippe Zizzari
Martine Perret
Jacques Epelbaum
jacques.epelbaum@inserm.fr
Centre de Psychiatrie & Neurosciences, UMR 894 INSERM, Faculté de Médecine, Université Paris Descartes, France.
The development of biological markers to evaluate individual life-span is badly needed because of the high cost and time duration that are necessary to assess the ageing process in long-living organisms such as primates. In this study, we measured insulin-like growth factor-1 (IGF-1) levels in a small, relatively short-living (maximal longevity: 12 years) primate from Madagascar, the gray mouse lemur (Microcebus murinus), in order to determine if they can be related to the rate of survival of this seasonal species. Cross-sectional blood samplings on 112 males of various ages indicated that IGF-1 levels remain high and constant during the long-day breeding seasons while a significant age-related decrease occurs from the fourth short-day resting season onward. Interestingly, in four-year-old lemurs, short-day IGF-1 body mass ratio values appeared as a good predictor of their life-span.

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Supporting Agencies

UMR CNRS/MNHN7179, UMR 894 INSERM-Paris Descartes
Jacques Epelbaum, Centre de Psychiatrie & Neurosciences, UMR 894 INSERM, Faculté de Médecine, Université Paris Descartes
Since the beginning of my research, I have been working on neuropeptides and their function in brain, particularly on somatostatin. From 1991 on, we demonstrated the presence of somatostatin receptors on GHRH neurons in the hypothalamus and studied their functions in the intrahypothalamic network involved in the control of GH secretion. We also demonstrated the presence of somatostatin receptors on different human tumor types that led to the use of somatostatin agonists in the management of pituitary and neurroendocrine tumors. We also characterized the somatostatin deficits linked to age-associated diseases such as Alzheimer disease dementia. Since 2000, we are also investigating the role of preproghrelin derived peptide in the neuroendocrine control of GH secretion, feeding behaviour and energy balance. 184 articles in medline, 88 reviews or book chapters and more than 400 abstracts. I authored 5 books et gave 155 invited seminars or conferences (24 since 2004)

How to Cite

Aujard, F., Bluet-Pajot, M. T., Zizzari, P., Perret, M., & Epelbaum, J. (2010). IGF-1: a marker of individual life-span in a primate. Ageing Research, 1(1), e2. https://doi.org/10.4081/ar.2010.e2

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